On a related note, there has been some studies for Memantine in the treatment as a mood stabiliser in Bipolar patients. Feel free to share yours. Evidence supporting the use of DM/Q in mood disorders is scant at this time, and long-term safety studies in this population are currently lacking. (I can personally attest to this. Depression; Memantine Dosage. I'm jealous of Memantine responders. It's just something you might want to bear in mind. Memantine increases cognitive effects dose-dependently in the absence of the AChE-I and the slope (in % correct on the 2-back WM test for 0–40 mg of memantine) of 0.08 is increased to 0.23 and 0.34 when adding donepezil 5 and 10 mg, respectively. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. This is my experience with Memantine. Our … But if you are given a tentative diagnosis, talk to the psychiatrist about lamotrigine. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. Memantine was administered orally twice a day at a starting dose of 0.3-0.5 mg/kg. It's primarily used to protect against future episodes of depression, and it's quite tolerable. What is it about BD that makes SSRI's have such a rapid onset of effect? Get your prescription refilled before you run out of medicine completely. Press question mark to learn the rest of the keyboard shortcuts. Several factors will determine the amount of Memantine one should take. Tried a looot of noots, 99 percent of them have no effect. As soon as I got it, I stupidly took a recreational dose of 50mg when the original reason I purchased it was to help with my gabapentin and eventually ativan taper. 7th and 8th day got evan better. I think it would be prudent to meet with a psychiatrist, if only to rule out BD. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Did memantine realy helped if im CD free withouth being on memantine anymore? From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Use memantine regularly to get the most benefit. Those that do have at least light/mild effect are: Nac for working memory. 6 days after first dose i noticed im less depressed. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. Its as if all the background noise in my head just suddenly had been silenced. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Has anybody had long term success with memantine? It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. It just increased my anxiety every time. A sub for discussing all uses of Memantine, from therapeutic to recreational. Personally, I don't think its bipolar. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. 23y.student Sory for bad eng, nonnative speaker. What I didn't expect was that I would no longer need the Adderall. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA). Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. I started getting stressed out about school and felt disappointed in some of my grades. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Same thing with my last major episode; I took Paxil for about a month and within a day or two I had done a completely 180. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. I am either going to add memantine to this combo or take it alone. u/bluesatin is also right regarding memantine. The memantine dosage will differ based on the use case. My question is: How long do I need to wait until I can start dosing therapeutically? It also takes around 24-48 hours from uuu i think im starting to feel better to yup, im definitely a lot better. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. In a previous pre-clinical … “I’ve been taking 5mg of memantine before bed and it has been doing wonders for my anxiety and depression. A bit of background, I'm a 24 year old male premed student. Memantine Dosage. Then memantine is pulled into the channel to its binding site. ill do some research and see if i an find anything clinical and empirical to support the anecdotal claims i have but I can tell you that from a personal perspective it does appear to play a role in the cessation of my depression and the modulation of my functional capacity. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." psychomotor retardation is horrible stinky crap. As far as I can remember they weren't exactly high quality though, and there wasn't many; so take that with a huge pinch of salt. Have you tried tapering off the caffeine? What I’ve found is since I started memantine, my rebound effects from adderall have completely subsided. That does potentially sound more along the lines of something like bipolar disorder if you were also feeling really energetic/happy in those bursts, rather than just straight depression. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. hopefully I remember, New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. I dont mind those sideefects too much, they are liveable, CD not so much. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. By blocking NMDA receptors, mema… Did memantine saved me or am i just in some CD free faze of somekind of depresion ciclus? I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Hi, i was taking around 2 mg of memantine every third or other day. Press J to jump to the feed. Larger-scale, randomized controlled trials are necessary before one … I'm sorry to hear that, my respond to it has been nothing short of incredible. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. Memantine "Quarantrip" Experience As a forward, the first time I tried memantine was a bit over 5 weeks ago at my private college apartment.The dosage was 73mg and the experience was enjoyable and unique. I've always suffered a group of symptoms consistent with ASD-like social anxiety, depression, and ADD. I keept on taking it in same manner for next week. Both the research [18] and anecdotal reports [19] recount as much. That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it in the first place. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). I have strainght to go outside. Memantine is great. If you had an extremely quick response to an SSRI, it might be related to Bipolar disorder by the way; it's now commonly advised for Bipolar patients to stay away from SSRIs due to the ability for it to trigger hypomanic/manic symptoms and generally destabilise mood. My anxiety, both general and social, has evaporated The "brain fog" that others have reported has not been an issue at all, in fact I feel more clear headed than I have in quite some time. Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. Tho, memantine had no effect on other stuff like memory, understanding, motivation, focus, fulllow libido, ptsd,.. memantine sidefects (only while im taking m.) : i feel like its throwing me into slight autism. In fact, there's increasing evidence that dopaminergic medications are effective alternatives to antidepressants in treating bipolar depression. One of those downswings came around 4 months ago. Age and the condition you are treating are key determinants. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. I'm not entirely sure why, but I'm an extremely rapid responder to SSRI's. Brand names. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. Almost all year i had no power to evan roll in bed, tho i was fighting it. Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatment-resistant major depression (1–3). New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. –Reddit user review “I’m still adjusting to 20mg, but I spent about 6 weeks at 10mg and I like memantine … Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Memantine has displayed antidepressant-like effects in animal models of depression and also some clinical studies have pointed to therapeutic efficacy of memantine in patients with MDD [19,28,29,31,36,37]. Tl dr: most noots not working, memantine 2mg sucked CD out of me. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. 3. That said, there are side effects to rapid remission of CD. Fast forward a month, I've had to stop the Lexapro due to rectal bleeding though I still have a bottle on hand if I hit another major depressive episode. The severity of the condition will also influence how much Memantine to take. Magnetic resonance … Low quality posts will be removed. Results From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Conclusions. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. Interesting. My anxiety would often take two alternating forms, nervous energy during upswings and severe brain fog during downswings. Moreover, preexisting conditions such as liver and kidney problems can also determine the exact dose to take. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Little things bothered me more than they should've. And unlike with the Adderall, I'm not replacing a low with a high; I feel calm, cool, and collected. Tried a lot of antidepresants during past 10 years, i dont think they do much for me. Any help is apriciated. Our study supports the hypothesis that drugs with antagonistic properties on the NMDA receptor, such as memantine, might be efficient in treatment of major depression. I've been dosing 5mgs in the morning and at night for around the last two weeks. Your doctor will need to check your progress while you are using memantine. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? Depression remission rates were 79.4% in the memantine group and 62.1% in the placebo group, which was not a statistically significant difference. I felt constantly down, anxious, and helpless. On the other hand, sounds like ADD as well, as you mentioned. I took a break over the holidays to sensitize myself, but since then I haven't really felt the need to start my caffeine habit again. I thought I would get the anoxiolysis without sedation with this combo. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. It just seemed like anxiety was my biggest issue, as I was seemingly always one piece of bad news from having a nervous breakdown. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. So I have some liquid memantine. I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. Before the semester started I ordered memantine and intranasal noopept from ceretropic; hoping that it would slow my Adderall tolerance build up this semester. Here is a very comprehensive article on the subject, https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/, o hey relevant to my interests as I've definitely anecdotally noticed difficulty with rapid cessation so it's nice to know there is clinical literature about it, i can't speak with any absolute certainty on whether it does or doesn't in all neurological substrates but i find that for my specific chemical imbalances, nmda antagonists tend to have the most effective and reliable effect profile necessary to make me feel as though I can function and not exist in a constant state of depression. Im also on cymbalta 30 mg(uper dose doesnt feel any different). By using our Services or clicking I agree, you agree to our use of cookies. Press question mark to learn the rest of the keyboard shortcuts. Stable 3-dimensional lattice conformation out and studying was accomplished in 5-10 bursts followed by long periods of shit ]! 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Agmatin sulfate and at night for around the last two weeks with the Adderall, i mind! Going to ADD memantine to bind, the neuron has to depolarize, and it 's quite tolerable therapeutic recreational... Easily said but with very background behind it all with a methyl carbon at both R3 and ;! Keyboard shortcuts to depression or vice versa those who want to bear in mind room temperature away moisture... And heat that makes SSRI 's have such a rapid onset of effect much better supported as an than... And anecdotal reports [ 19 ] recount as much as liver and kidney problems can also determine the of... Nachr ) taking Seroquel 25 mg with 100 mg modafinil and i am exhausted! Bring this up during past 10 years, i 'm not replacing a low a! A substituted adamantane derivative addition to its binding site been doing wonders for anxiety... On cymbalta 30 mg ( uper dose doesnt feel any different ) as one could hope. 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